Low Ovarian Reserve - Challenging Situation in Fertility Management

LOW OVARIAN RESERVE - CHALLENGING SITUATION IN FERTILITY MANAGEMENT

Women are born with a limited egg reserve which starts depleting with age and hence the natural fertility also declines. But there are clinical situations where younger woman of around 30 years of age face an issue of low ovarian reserve. It means that the ovaries have aged more than the biological age. This clinical situation is a challenge both to the fertility specialist and the couple.

We would like to share some interesting cases of low ovarian reserve.

VM, a 32 year old woman approached our fertility and IVF center. She was a case of Primary amenorrhea (MRKH syndrome - a rare genetic case of absent uterus). We did all her tests and found she also had a poor ovarian reserve, as her AMH (blood test to know the ovarian reserve) was low and both the ovaries were small on Sonography. Her husband’s semen analysis report was normal. For her to get her own biological child,an embryo made from her eggs and fertilized by her husband’s sperm had to be transferred in a Surrogate. We used hormonal injections to stimulate her ovaries but there was no response in the 1stcycle. She responded in the second cycle and on egg retrieval, we got only 2 eggs, these were fertilized with her husband’s sperms. Two good quality embryos were transferred in the surrogate and to everyone’s luck, she conceived and is now 8 months pregnant.

SM, a 32 year old woman approached us for fertility issues. Her husband had no sperms in his semen. On doing some blood tests, it was found that the sperms were maturing in his testis but were absent in the semen. We first did a surgical retrieval of the sperms from the epididymis (PESA) and froze the sperms. A diagnostic Hysteroscopy(thin telescope to visualize the cavity of the uterus) was performed and it showed some adhesions which were released. Her egg reserve was also low. We then treated her with hormonal injections. We were a bit disappointed as we got only one egg. The PESA sperm was injected into the egg by Intracytoplasmic sperm injection (ICSI). The embryo was then transferred in her uterus. To our happiness, she had conceived and to our great surprise she had twins as the embryo had divided inside the uterus. She is now 12 weeks pregnant.

VN, a 36 year old woman with a low ovarian reserve approached us for treatment. She had undergone 2 IVF cycles and had not conceived. After the usual investigations, we used hormonal injections and got 5 eggs, and all 5 fertilised with ICSI. We were really happy. We did a sequential transfer in her. We transferred 3 embryos on day3 and 1 blastocyst transfer on Day 5. She too conceived. Shehad an extremely rare problem in her 6th week of pregnancy; we had to perform an operative laparoscopy to control the bleeding from the left ovary. Her intrauterine pregnancy was not disturbed and it continued till term. She is now a proud mother of a one year old son.

So as seen here there are many challenging situations for a fertility specialistand low AMH is one of them.  One needs to be perseverant and not give up. Very often we need to use donor eggs from a younger woman. Another important point to remember is that if the woman has not found her right partner, she can freeze her eggs at a younger age and use them at a stage when she feels confident in becoming a mother.

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Fertility Treatment / IUI

We are happy to have treated more than 20,000 couples with fertility issues. IUI is simple treatment for couples with unexplained Infertility, PCOS, early endometriosis Know More

IVF Treatment

Indicated in couples with tubal blockage, repeated failed IUI and endometriosis. Results range across 40 -50% at our centre Know More

ICSI Treatment

Treatment of choice for male infertility with very low sperm count, obstructive azoospermia and for coupes requiring donor eggs. Know More

Fertility Preservation

Many young men and women have utilized our fertility preservation services in the form of sperm, egg and embryo freezing either for medical or social reasons Know More

Maternity Care

More than 3000 women have delivered at our centre. They have had an exceptional experience in antenatal care, delivery and postnatal care. Know More

Laparoscopy

We have been performing all Gynaec surgeries through Laparoscopy for the past 25 years. Advantages are it is safe, less painful Know More

Hysteroscopy

Hysteroscopy has many advantages over traditional D & C. We are equipped with small telescope to diagnose and treat pathologies inside the uterine cavity Know More

Fibroids

Fibroid causes infertility, pain and excessive menstrual blood loss. They can be operated through Laparoscopy or Hysteroscopy Know More

Endometriosis

Endometriosis causes infertility and painful periods. Best treatment is initiated by Laparoscopy surgery and drugs Know More

Hysterectomy

We have been performing laparoscopic hysterectomy for the past 25 years. It is a definitive treatment for heavy menstrual bleeding, fibroids, cancer Know More

Ectopic

Ectopic is a condition where the pregnancy gets implanted in the fallopian tube instead of the uterine cavity. We have operated many cases laparoscopically Know More

Post-menopausal Bleeding

Hysteroscopy helps in evaluating the cause of Postmenopausal bleeding Know More

Our Doctors

Dr. Sudha Tandon

MD. DGO.,

Gynaec Endoscopy Surgeon Fertility and IVF Consultant

Dr. Aditi Tandon

M.S. Obgy,

Fellowship in Reproductive Medicine and IVF (London), Minimal Access Surgery and Ultrasound

Dr. Amrita Tandon

MS, DNB Obgy,

Fellowship in Reproductive Medicine and IVF (London), Minimal Access Surgery and Ultrasound

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Any Queries?

What is infertility ?

If the couple has regular intercourse, does not use any contraception and still does not conceive within one year, they are said to be infertile. 80-85% of the couples conceive within one year of unprotected intercourse i.e. without the use of any contraceptive. However, the rest 15-20 % who are unable to conceive naturally are said to be infertile and these would require proper evaluation and help for getting pregnant.

Does fertility depend on age?

Yes, in a woman fertility does depend on her age. A young woman is naturally more fertile as she has more number of good quality eggs than a woman who is 35 +. Hence a woman who is 35 + should not wait for a long period for a natural conception and should seek help from a proper fertility expert. Also the chance of genetic abnormalities and medical complications like Hypertension and Diabetes increases with age.

When should a couple seek medical help for infertility?

If the woman is below 35 years and has normal menstrual periods, and the couple has tried for a conception for a year with a frequency of sexual intercourse 3-4 times a week during the fertile period and has yet not conceive, then they need to consult an Infertility expert.

How does body weight, diet & exercise affect fertility?

For increasing the chance of pregnancy, balanced body weight of the woman would be beneficial. Being obese or grossly underweight affects the maturation of eggs in the woman and hence may affect her fertility. Also, a grossly obese woman would have mechanical difficulty in having normal sexual relations. Regular, moderate exercise especially in the form of yogasanas, walking, swimming, or jogging prove beneficial for fertility. It has been observed that strenuous form of exercises for example jogging over 3 miles a day can hamper ovulation and hence may lead to decrease in fertility in the woman. Balanced and nutritious diet help increase the chances of conception and ensure proper growth of the fetus.

Is stress a major factor in infertility?

Chronic stress may interfere with the ovulation, may decrease the sexual desire and hence affect the frequency of sexual intercourse in the couple.

How would one know the cause of infertility?

A detailed history of both partners is very helpful in giving a clue to the cause of infertility. For e.g. anovulation is the cause of infertility in a woman who has irregular periods and who is also obese, blocked fallopian tubes in a woman with previous history of pelvic infection, low sperm count in a man with past history of mumps. Examination of both the partners, and getting the required investigations would give a complete picture.

What are the most stressful stages of IVF?

A natural conception is obviously what all couples desire and wish when they plan a pregnancy but when it does not happen and the couple is counselled for an IVF treatment, it creates lots of stress for them.

The most stressful part is the acceptance of the fact that IVF is the only best option for their problem. A good discussion with the doctor to understand about Human Reproduction and why IVF is the best option for them to conceive will help the couple .They should take their time to understand about what the treatment involves and always ask questions to get their doubts cleared. A session with the counsellor would definitely help. Speaking to friends and family who are knowledgeable is a good way to reduce the stress but at times it could be counterproductive especially if they only talk of the problems and are themselves not positive.

In an IVF treatment, the woman’s eggs and her partner‘s sperms are fertilised in a laboratory. To get her eggs, she needs to take hormonal Injections on a daily basis and at the same time every day. This could create some stress especially if she is in a demanding job. It is best that she confides in someone who is reliable and understands the intricacies of an IVF treatment. The best part is that these Injections are not painful as very fine needles are used and she could also self-administer it.

She needs to see her fertility specialist for the follicular tracking for about 4-5 times in a cycle. This could also be demanding and stressful. She should just take all this in her stride and not get unduly stressed. The follicular response may not be satisfactory especially in a woman with poor ovarian reserve and she could become stressed.

She could have stress on the day of egg retrieval because of the fear of pain but this is a small procedure which is done under safe anaesthesia. The procedure is done through the vagina and there are no cuts on her abdomen. This is simple and safe procedure, not painful. At times the male partner gets stressed and is unable to give his semen sample on the day of egg pickup. To avoid this problem, almost all fertility centres will freeze the semen sample beforehand as a backup.

Of course the other stressful point is to worry about the numbers and quality of eggs got at the time of pickup, the fertilization of the eggs, and the numbers of good quality embryos. All these are important form success point of view. A communication with the couple before the procedure will allay all their fears and will go a long way in taking care of the stress.

The most important step in IVF Treatment

The most important step in IVF is Embryo transfer for which the woman should relax. Generally it is done without anaesthesia. The woman‘s cooperation is so very important for favourable results.

After the embryo transfer one has to wait for about 10 days to know the results. It could be very stressful at this stage. She should try to be calm and not just keep thinking of the results. After the embryo transfer the woman has to use either progesterone vaginal tablets or Injections and the stress of finances adds to the stress of procedure.

All in all we do understand the stress that the couple undergoes for an IVF treatment cycle. Have trust in your doctor and you would definitely become a successful.

At our IVF Clinic in Mumbai and IVF centre in Navi Mumbai, we spend quite a lot of time to make you feel comfortable. Our entire support staff and our embryologist are in constant touch with the couple. We try to see that you do not have to wait for too long to see the doctor. We have all facilities of Hysteroscopy/ Laparoscopy / IVF treatment and Maternity at Dr Sudha Tandon centre and we take utmost care of our patients.

Mumbai Centre
Dr. Sudha Tandon's Fertility & IVF Center

4th Floor, Gagangiri Complex 18th Road, Near Dr. Ambedkar Udyan Chembur (E). Mumbai 400 071.

+91 91676 80410 / 022 25260390 / 022 25260391

Navi Mumbai Centre
Dr. Sudha Tandon's Fertility & IVF Center

6, Archana CHS, Gr. Floor, Sector 17, Plot No. 18, Vashi, Navi Mumbai 400 703.

+91 98330 44930 / 022 27802188